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Indicators measured at clinic visits, such as blood eosinophil counts and FeNO, can signal whether inflammation is off-target or if a previously T2-low patient has shifted to T2-high due to certain changes—such as discontinuation of ICS or exposure to new allergens—and vice versa

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159 Based on these studies, in liver cancers, a dinucleotide base signature was identified and attributed to acetaldehyde exposure, comprised primarily of CC → AA changes and additionally lower levels of CC → AG and CC → AT changes