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In an embodiment, provided herein are compositions comprising donor RNA sequences comprising endogenous RNA sequences, heterologous RNA sequences and a linker sequence to be used in trans-splicing onto pre-mRNA transcripts that allow for the facile release of heterologous protein sequences
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Branched-chain amino acid levels, typically reduced in cirrhosis patients, were restored through supplementation, which alleviated muscle cramps, particularly with higher and nocturnal doses, yielding minimal self-limiting adverse events
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