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Specifically, the enzymatic activity and transcript abundance of glutathione synthetase, the enzyme for the second reaction, was upregulated rapidly and significantly in infested resistant plants

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Although early research focused mostly on binary mixtures, work done after 1998 has made important advances to the study of multicomponent combinations including 3, typically 5, and up to 12 estrogenic compounds (Kortenkamp and Altenburger, 1998)