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TB-500's lineage traces instead to thymosin beta-4, whose complete amino-acid sequence was characterized by Low, Hu, and Goldstein in 1981, with its actin-sequestering role established in subsequent structural and biochemical work through the 1990s and 2000s [2,3]
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Most therapeutic research remains centered around experimental models of disease in rodents with limited work in the larger species, arguably narrowing the utility of these findings in horses on a clinical level
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