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Glutamine's involvement in MnSOD expression was blocked by inhibiting the TCA cycle, ERK1/2 or mTOR, suggesting that an integration between mitochondrial glutamine metabolism and signal transduction facilitates the effect
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Biodistribution and toxicity evaluations further indicated that CMH@lip@Res-TCeO 2 did not accumulate in major organs up to 48 h post-injection (Figures S15A-B)
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