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Up-Regulated microRNA-411 or Declined RIPK1 Inhibits Proliferation and Promotes Apoptosis of Synoviocytes in Rheumatoid Arthritis Mice via decreased NF-κB pathway
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Because the receptor needed binding at extremely high affinity, in the low picomolar range, small-molecule chemistry could not do the job precisely enough, so the team built an antibody instead, screening thousands of candidates for the stickiest binder (47:52)
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