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Some studies have also found that taking vitamin D and calcium together can help prevent leg cramps, but larger studies are needed to confirm these findings
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In some embodiments, preparation of certain cations of the invention may occur via oxidation of quinoline (using e.g., mCPBA) followed by nitration and chlorination, respectively and further followed by amination and alkylation, respectively, as exemplified with the preparation of cation 2k (Scheme 4)
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