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the deficient patients also presented more severe pneumonia (lower ratio of partial pressure of oxygen/fraction of inspired, more days on mechanical ventilation, lower hematocrit, and hemoglobin levels) [186]

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These down-regulate the C-C Motif Chemokine Ligand (CCL)20 and CCL22 expression and their receptors in EAE mice, inhibiting the leukocytes infiltration into the CNS, an essential step in the MS pathogenesis, and improving the clinical symptoms, and the pathological scores of disease (Jafarzadeh et al., 2014, 2015, 2017)