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substitution reactions) Table of Contents The Acidity Constant K a and Its Negative Logarithm pK a The Four Components of an Acid Base Reaction The Principle of Acid-Base Mediocrity Using pK a values and the Principle of Acid-Base Mediocrity To Predict Acid-Base Reactions How to Use pK a Values to Determine Basicity How to Use a pK a Table To Determine If An Acid-Base Reaction Is Favorable How To Determine The Acidity of Compounds That Aren’t On A pK a Chart Applying pK a In Substitution Reactions Summary Notes Quiz Yourself