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Beyond the role of glutamate as a neurotransmitter | Nature Reviews Neuroscience

Clinical studies also investigated its effects on pain perception in subjects with chronic pain conditions

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Thus, it is important that a chelator satisfy criteria that allow it to: (1) transport across physiological barriers into compartments where a toxic metal ion is concentrated, (2) form a stable complex with the metal after removing it from the biological chelator, if required at the site and (3) form a chelation complex whose properties render it non-toxic and facilitate its excretion, not only from the site of deposition, but also from the body [3]