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While a substitution with the polar serine at position 13 retained wild-type dehydratase activity, presumably due to the alcoholβs ability to assume cysteineβs function in stabilizing deprotonated GS β , the only other Pt GSTF8 variants to keep anβalbeit reducedβflavan-3,3,4-triol ( 4 ) dehydration activity contained a glycine, alanine or asparagine mutation (Fig
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