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In the genetic absence of HSL, this transacylase activity of PNPLA2 promoted more efficient lipolysis by acylating DAG to generate MAG substrate for MGL (23)

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Modeling HPA dysfunction in rodents In this section, we will describe four (non-exhaustive) approaches to alter HPA function, as well as the wider brain circuits involved in stress responses, in order to understand how they contribute both to normal, and abnormal, neurobehavioral responses to stress