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Pharmacological inhibitors of ULK1 (e.g., MRT68921, SBI-0206965), along with inhibitors of other key initiation nodes such as lipid kinase VPS34 (e.g., 3-methyladenine, wortmannin, LY294002) and the PI3KC3-C1 complex (e.g., Spautin-1, SAR405) have primarily demonstrated efficacy in vitro and in mouse models of various other cancers

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