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Malecha 2 , Jing Li 2 and Alan Bonder 3 , (1)Robert G Gish Consultants LLC, (2)Intercept Pharmaceuticals, Inc., Morristown, NJ, (3)Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School Background: Transient elastography (TE) is a widely used, non-invasive method of evaluating hepatic fibrosis, a key prognostic factor in primary biliary cholangitis (PBC)

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While mammals have only one copy of the GPX4 gene, fish have two copies, GPX4a and GPX4b