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Exenatide, a synthetic variant of exendin-4, incorporates strategic modifications that substitute asparagine (Asn) at the C-terminal with aspartic acid (Asp) and swap alanine (Ala) at the 8 th position with glycine (Gly)
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9 Genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) linked to OA risk and highlighted how genetic variations can predispose individuals to the disease by altering their responses to mechanical stress and inflammatory processes
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