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Abbreviations: ALI: acute lung injury, BALF: bronchoalveolar lavage fluid, CFU: colony forming units, CS: cigarette smoke, EMT: epithelial–mesenchymal transition, eNOS: endothelial nitric oxide synthase, ET-1: endothelin-1, GST: glutathione, HMGB: high-mobility group box, IL-5: interleukin-5, iNOS: inducible nitric oxide synthase, LPS: lipopolysaccharide, i.g.: intragastric administration, i.n.: intranasal administration, i.p.: intraperitoneal administration, i.t.: intratracheal administration, MMP: matrix metalloproteinase, NOx: nitric oxide metabolites, p.o.: peroral administration, PFU: plaque-forming units, PBCA-NPs: EGCG-encapsulated poly(butyl-2-cyanoacrylate) nanoparticles, RAGE: receptor for advanced glycation end products, ROS: reactive oxygen species, SOD: superoxide dismutase, TGF-β1: transforming growth factor-beta1, TNFα: tumor necrosis factor alpha, ↓: decrease, ↑: increase