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While the study concluded that short-term DSIP treatment was unlikely to be of major therapeutic benefit — noting that statistically significant effects were weak and partly attributable to incidental placebo group change — it provided the most methodologically rigorous human sleep architecture dataset for DSIP and confirmed the compound’s specific effect on objective, not merely subjective, sleep quality parameters

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10.1016/j.bbr.2025.115742 29 HunterK.HölscherC